Used in biomedical research to measure osteocalcin levels in human serum or plasma samples. Helps assess bone formation and turnover in studies related to osteoporosis, metabolic bone diseases, and endocrine disorders. Commonly applied in clinical laboratories and research settings to evaluate osteoblast activity and monitor response to bone-targeted therapies. Also used in studies exploring the role of osteocalcin as a hormone in glucose metabolism and energy regulation.