Used in biomedical research to quantify levels of soluble tumor necrosis factor receptor I in biological samples such as serum, plasma, or cell culture supernatants. Enables researchers to study inflammatory processes, immune system regulation, and disease mechanisms related to TNF signaling, including autoimmune disorders like rheumatoid arthritis, Crohn's disease, and sepsis. Supports evaluation of therapeutic interventions targeting the TNF pathway by monitoring receptor dynamics. Widely applied in preclinical studies and clinical research for biomarker analysis.