Used in bone metabolism research to quantify serum levels of TRACP-5b, a biomarker secreted by osteoclasts. Helps assess osteoclast activity and bone resorption in conditions like osteoporosis, Paget's disease, and bone metastases. Enables monitoring of anti-resorptive therapy effectiveness, such as bisphosphonate treatment. Provides a sensitive and specific tool for clinical studies and drug development related to bone diseases.