Used in biomedical research to quantify levels of TNKS1 (Tankyrase 1) protein in cell lysates or tissue samples. Enables study of Wnt signaling pathway activity, which is critical in cancer research, particularly for colorectal and other epithelial cancers. Supports investigation into telomere maintenance and insulin signaling due to TNKS1's role in these processes. Commonly used in drug development to assess target engagement of tankyrase inhibitors. Provides a high-throughput, sensitive method for screening compounds that modulate PARP activity within the tankyrase family.