Arotinolol Hydrochloride is a selective α1-adrenergic and non-selective β-adrenergic receptor antagonist used primarily for the treatment of essential hypertension. It exerts its antihypertensive effects by blocking α1-receptors to promote vasodilation and reduce peripheral vascular resistance, while β-blockade decreases heart rate and cardiac output. This dual mechanism makes it effective for patients with hypertension, particularly those with associated cardiovascular risk factors. It is approved for clinical use in certain countries, such as Japan, but not widely available elsewhere. Also utilized in pharmacological research.