tert-Butyl 5-bromo-3-(hydroxymethyl)-1H-indole-1-carboxylate
98%
Reagent
Code: #146027
CAS Number
905710-14-7
blur_circular Chemical Specifications
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Molecular Information
Weight
326.19 g/mol
Formula
C₁₄H₁₆BrNO₃
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Registry Numbers
MDL Number
MFCD05864710
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Physical Properties
Melting Point
105-107°C
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Storage & Handling
Storage
Room temperature, dry
description Product Description
Used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of serotonin receptor modulators and other central nervous system agents. Its functional groups—bromine, hydroxymethyl, and protected indole nitrogen—allow selective cross-coupling reactions, such as Suzuki or Negishi couplings, enabling the construction of complex indole-based structures. The hydroxymethyl group can be further derivatized to esters, ethers, or aldehydes, expanding its utility in medicinal chemistry. Commonly employed in research settings for generating analogs in drug discovery programs targeting neurological disorders and inflammation.
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