tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate
97%
Reagent
Code: #149517
CAS Number
777061-36-6
blur_circular Chemical Specifications
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Molecular Information
Weight
343.23 g/mol
Formula
C₁₉H₂₆BNO₄
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Registry Numbers
MDL Number
MFCD05663895
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Physical Properties
Melting Point
131 - 136 ℃ - lit.
Boiling Point
454.6 ℃ at 760 mmHg
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Storage & Handling
Density
1.08 g/cm3
Storage
2-8°C
description Product Description
Widely used in organic synthesis, particularly in cross-coupling reactions such as Suzuki-Miyaura coupling, this compound serves as a key intermediate for introducing the indole moiety into complex molecules. Its boronate ester group allows for efficient and selective bond formation with aryl or heteroaryl halides, making it valuable in pharmaceutical and agrochemical research. The tert-butyl carbamate-protected indole nitrogen ensures stability during reactions and can be deprotected under mild acidic conditions when needed. This compound is especially useful in the development of bioactive molecules, including drug candidates targeting neurological disorders, inflammation, and cancer.
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