tert-Butyl 3-bromo-5-nitro-1H-indole-1-carboxylate
98%
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Used as an intermediate in the synthesis of pharmaceutical compounds, particularly in the development of indole-based bioactive molecules. This N-protected derivative features a tert-butoxycarbonyl (Boc) group on the indole nitrogen, which prevents unwanted side reactions during synthesis and can be easily removed under mild acidic conditions. The bromo substituent at position 3 and nitro group at position 5 enable further chemical modifications, such as cross-coupling reactions (e.g., Suzuki-Miyaura) and reductions, making it valuable in constructing complex heterocyclic systems. Commonly employed in medicinal chemistry for creating potential kinase inhibitors and anti-inflammatory agents. Also utilized in research settings to develop fluorescent probes and functionalized indole derivatives for biological studies.
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