WAY-622081 is primarily used in scientific research to investigate inflammatory pathways and immune responses. It functions as a potent and selective antagonist of the prostaglandin E2 receptor subtype EP4, making it a valuable tool in studying conditions where EP4 receptor signaling plays a role, such as arthritis, pain, and certain cancers. Researchers utilize this compound to explore the modulation of cytokine production, T-cell differentiation, and vascular permeability in preclinical models. Its high selectivity allows for targeted disruption of EP4-mediated effects without significant off-target activity, supporting its use in mechanistic studies and potential therapeutic development.