FR167344 free base is a potent and selective inhibitor of p38α and p38β mitogen-activated protein (MAP) kinase isoforms. It is primarily utilized in scientific research, particularly in the study of biochemical pathways and cellular processes. It is often employed to investigate the role of p38 MAPK in biological systems, with applications in understanding mechanisms related to inflammation, immune response, and signal transduction. Its use helps in identifying potential therapeutic targets for various diseases, including autoimmune disorders and chronic inflammatory conditions. Additionally, it serves as a valuable tool in pharmacological studies to assess the efficacy and safety of new drug candidates.