PAC-14028 is a TRPV1 ion channel inhibitor primarily used in dermatology and skincare for treating inflammatory skin conditions such as atopic dermatitis. By inhibiting TRPV1, which is involved in pain perception and itching, it reduces skin inflammation, itching, and improves skin barrier function, enhancing patient quality of life. It is applied in topical formulations like creams or ointments and studies confirm its efficacy and safety in both children and adults. Research continues for broader dermatological applications.