IKK-16 HCl is primarily utilized in research settings to study inflammatory pathways and related diseases. It acts as a potent inhibitor of IκB kinase (IKK), which plays a critical role in the activation of NF-κB signaling. This makes it a valuable tool for investigating conditions such as chronic inflammation, autoimmune disorders, and cancer, where NF-κB is often dysregulated. Researchers use IKK-16 HCl to explore potential therapeutic strategies by blocking this pathway, thereby reducing inflammation and cell proliferation. Its application extends to preclinical studies aimed at understanding the molecular mechanisms underlying these diseases and evaluating the efficacy of targeted treatments.