Polygodial is primarily known for its potent antimicrobial and insecticidal properties. It is commonly used in agricultural settings as a natural pesticide to protect crops from various pests, including insects and fungi. Its ability to disrupt the cellular membranes of target organisms makes it effective in controlling infestations without relying on synthetic chemicals. In addition to agriculture, polygodial is explored in the food industry as a natural preservative to extend the shelf life of perishable products by inhibiting microbial growth. Research also suggests its potential in medical applications, particularly in developing antimicrobial agents to combat resistant bacterial strains. Furthermore, its anti-inflammatory properties are being studied for potential use in pharmaceuticals to treat conditions like arthritis or skin irritations.