Used as a key reagent in organic synthesis, particularly for the preparation of isocyanides through the dehydration of formamides. It enables mild and efficient conversion, making it valuable in the construction of heterocycles and in multicomponent reactions such as the Ugi and Passerini reactions. Its ability to act as an oxidizing agent under gentle conditions allows for selective transformations in complex molecule synthesis, including natural products and pharmaceuticals. Also employed in hypervalent iodine chemistry for C–H functionalization and oxidative cyclizations.