The JAK2 JH2 Tracer is primarily used in biochemical research to study the Janus kinase 2 (JAK2) enzyme, particularly its pseudokinase domain (JH2). This tracer is instrumental in understanding the role of JAK2 in signal transduction pathways, especially those related to cell growth, survival, and differentiation. It is often employed in assays to investigate the mechanisms of JAK2 mutations, which are implicated in various myeloproliferative disorders such as polycythemia vera, essential thrombocythemia, and myelofibrosis. Additionally, the tracer aids in the development and screening of potential therapeutic inhibitors targeting JAK2, contributing to advancements in treatments for related hematologic cancers and autoimmune diseases.