AS 1949490 is primarily utilized in research settings as a selective inhibitor of the enzyme sphingosine kinase 1 (SphK1). This enzyme plays a critical role in the sphingolipid metabolism pathway, which is involved in various cellular processes, including cell growth, survival, and inflammation. By inhibiting SphK1, AS 1949490 helps researchers study the effects of sphingolipid signaling in diseases such as cancer, inflammatory disorders, and autoimmune conditions. Its application is particularly valuable in preclinical studies to understand the potential therapeutic benefits of targeting SphK1 in these diseases. Additionally, it serves as a tool compound to explore the broader implications of sphingolipid biology in cellular and molecular mechanisms.