INCB053914 phosphate is primarily used in the field of oncology as a targeted therapeutic agent. It functions as a potent and selective inhibitor of PIM kinases, which are often overexpressed in various cancers. By inhibiting these kinases, it disrupts signaling pathways that promote cancer cell survival, proliferation, and resistance to apoptosis. This makes it a promising candidate for the treatment of hematologic malignancies, such as multiple myeloma and acute myeloid leukemia, as well as certain solid tumors. Clinical trials are ongoing to evaluate its efficacy, safety, and potential use in combination with other anticancer therapies. Its application represents a targeted approach to cancer treatment, aiming to improve outcomes for patients with limited therapeutic options.