KHS-101 is primarily used in neuroscience research as a potent and selective inhibitor of the protein TRIB2, which plays a role in cell survival and proliferation. Its application is significant in studying the mechanisms of neurodegenerative diseases, particularly glioblastoma, as it has shown potential in inducing apoptosis in cancer cells. Researchers utilize KHS-101 to explore its effects on tumor growth inhibition and its ability to cross the blood-brain barrier, making it a promising candidate for developing therapeutic strategies against brain cancers. Additionally, it is employed in preclinical studies to understand its impact on cellular pathways and its potential as a targeted therapy for other malignancies.