Rp-8-pCPT-cGMPS is widely used in biochemical and pharmacological research as a potent and selective inhibitor of cyclic GMP-dependent protein kinase (PKG). It is particularly valuable in studies aimed at understanding the role of PKG signaling pathways in various cellular processes, including smooth muscle relaxation, platelet aggregation, and neuronal function. Researchers utilize this compound to investigate the physiological and pathological effects of PKG inhibition, providing insights into conditions such as cardiovascular diseases, hypertension, and neurological disorders. Its application also extends to experimental models where precise modulation of cyclic GMP signaling is required to dissect the contributions of PKG in complex biological systems.