1-((2-(tert-Butyl)-4-(3-chlorophenyl)thiazol-5-yl)methyl)-3-(3-fluoro-4-(hydroxymethyl)phenyl)urea
98%
Reagent
Code: #130445
CAS Number
1933528-96-1
blur_circular Chemical Specifications
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Molecular Information
Weight
447.95 g/mol
Formula
C₂₂H₂₃ClFN₃O₂S
thermostat
Physical Properties
Boiling Point
600.1±55.0 °C(Predicted)
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Storage & Handling
Density
1.330±0.06 g/cm3(Predicted)
Storage
Room temperature, seal, dry
description Product Description
Used in pharmaceutical research as a potent inhibitor of specific kinases involved in inflammatory pathways, particularly studied for its potential in treating autoimmune diseases such as rheumatoid arthritis. Shows high selectivity for TYK2 (tyrosine kinase 2), modulating cytokine signaling linked to immune dysregulation. Demonstrates good oral bioavailability and brain penetration in preclinical models, making it a candidate for central nervous system-related inflammatory conditions. Also explored for psoriasis and lupus due to its ability to suppress IL-12 and IL-23 pathways. Currently in investigational stages, not yet approved for clinical use.
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