3-((4-(Piperazin-1-yl)phenyl)amino)piperidine-2,6-dione hydrochloride

95%

Reagent Code: #131715
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CAS Number 2259851-45-9

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 324.81 g/mol
Formula C₁₅H₂₁ClN₄O₂
inventory_2 Storage & Handling
Storage Room temperature, light-proof, inert gas

description Product Description

Used primarily in pharmaceutical research as a key intermediate in the synthesis of immunomodulatory agents and targeted protein degraders such as PROTACs, particularly those involving BTK (Bruton's tyrosine kinase) for the treatment of autoimmune diseases, certain cancers including multiple myeloma, and inflammatory conditions. Its structure enables selective modulation of signaling pathways involved in cell proliferation, immune response, and inflammation. Due to its functional groups, particularly the glutarimide and piperazine moieties, it is employed in the development of PROTACs (proteolysis-targeting chimeras), where it serves as a cereblon E3 ligase ligand to facilitate targeted protein degradation. It also supports inhibition of cytokine production and immune modulation in medicinal chemistry applications. Commonly utilized for lead optimization due to its favorable solubility and binding properties.

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿6,900.00
inventory 250mg
10-20 days ฿11,730.00
inventory 1g
10-20 days ฿31,660.00

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