1-(4-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
98%
Reagent
Code: #137902
Alias
Irrigational 11
CAS Number
936563-92-7
blur_circular Chemical Specifications
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Molecular Information
Weight
440.5 g/mol
Formula
C₂₅H₂₄N₆O₂
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Storage & Handling
Storage
2-8°C, sealed, dry
description Product Description
Used in pharmaceutical research as a potent inhibitor of Janus kinase (JAK) enzymes, particularly JAK1 and JAK3. It shows promise in the development of treatments for autoimmune diseases such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease due to its ability to modulate immune signaling pathways. Its acrylamide group enables covalent binding to cysteine residues in target kinases, enhancing selectivity and prolonging inhibitory effects. Also serves as a lead compound in the design of irreversible kinase inhibitors for oncology and chronic inflammatory conditions.
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