(3-Amino-2,6-Difluorophenyl)(5-(2-Cyclopropylpyrimidin-5-Yl)-1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Methanone
97%
Reagent
Code: #138947
CAS Number
1859158-65-8
blur_circular Chemical Specifications
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Molecular Information
Weight
391.37 g/mol
Formula
C₂₁H₁₅F₂N₅O
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Storage & Handling
Storage
Room temperature
description Product Description
Used as a key intermediate in the synthesis of Janus kinase (JAK) inhibitors, particularly in the development of pharmaceuticals targeting inflammatory and autoimmune diseases such as rheumatoid arthritis and psoriasis. Its structure enables selective inhibition of JAK1 and JAK2 enzymes, contributing to modulation of cytokine signaling pathways. This compound is also employed in structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of new drug candidates in clinical and preclinical research.
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