4-Amino-2-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1H-isoindole-1,3(2H)-dione
97%
Reagent
Code: #139224
CAS Number
253168-83-1
blur_circular Chemical Specifications
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Molecular Information
Weight
418.46 g/mol
Formula
C₂₀H₂₂N₂O₆S
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Storage & Handling
Storage
2-8°C
description Product Description
Used primarily as a key intermediate in the synthesis of Apremilast, a selective phosphodiesterase 4 (PDE4) inhibitor for treating inflammatory conditions such as plaque psoriasis and psoriatic arthritis. Its structure enables modulation of cyclic AMP levels, leading to reduced production of pro-inflammatory cytokines like TNF-α, IL-17, and IL-23. The 4-amino group allows for further derivatization, such as acetylation, to enhance the compound's pharmacological properties and selectivity. It is also utilized in research to develop novel small-molecule therapeutics targeting inflammatory pathways.
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