tert-Butyl (2-bromopyridin-4-yl)carbamate
98%
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description Product Description
Used as an intermediate in pharmaceutical synthesis, particularly in the development of kinase inhibitors and other biologically active compounds. Its structure, with a bromine substituent at the 2-position of the pyridine ring and a tert-butoxycarbonyl (Boc)-protected amino group at the 4-position, enables selective functionalization. The bromine allows for cross-coupling reactions to introduce diverse substituents at the 2-position, while the Boc group serves as a protecting group for the nitrogen, facilitating regioselective synthesis and improving solubility. After coupling, the Boc group can be readily removed under mild acidic conditions to reveal the free 4-amino group. This compound is valuable for constructing complex nitrogen-containing heterocycles and is commonly employed to introduce the 4-aminopyridin-2-yl moiety, which appears in several drug candidates targeting inflammatory diseases, cancer, and neurological disorders. It is also utilized in agrochemical research for designing novel pesticides and herbicides due to its stability and reactivity profile.
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