Triparanol
≥97% (HPLC)
Reagent
Code: #110144
CAS Number
78-41-1
blur_circular Chemical Specifications
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Molecular Information
Weight
438.00 g/mol
Formula
C₂₇H₃₂NO₂Cl
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Registry Numbers
MDL Number
MFCD00865748
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Physical Properties
Melting Point
102.9 - 103.7 °C
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Storage & Handling
Storage
2-8°C
description Product Description
Triparanol was primarily used as a cholesterol-lowering drug in the 1950s and 1960s. It works by inhibiting the enzyme responsible for the final step of cholesterol synthesis, thereby reducing cholesterol levels in the bloodstream. This made it a potential treatment for hypercholesterolemia and related cardiovascular conditions. However, its use was discontinued due to severe side effects, including the development of cataracts and other adverse reactions. Despite its withdrawal from the market, Triparanol remains significant in the history of pharmacology as an early example of cholesterol-lowering therapy, paving the way for the development of safer and more effective drugs like statins.
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Triparanol
Triparanol was primarily used as a cholesterol-lowering drug in the 1950s and 1960s. It works by inhibiting the enzyme responsible for the final step of cholesterol synthesis, thereby reducing cholesterol levels in the bloodstream. This made it a potential treatment for hypercholesterolemia and related cardiovascular conditions. However, its use was discontinued due to severe side effects, including the development of cataracts and other adverse reactions. Despite its withdrawal from the market, Triparanol remains significant in the history of pharmacology as an early example of cholesterol-lowering therapy, paving the way for the development of safer and more effective drugs like statins.
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