“Acetyl Hexapeptide-8 scope: randomized placebo-controlled study reported peri-orbital wrinkle improvement after topical argireline use.”
PepOil™ Acetyl Hexapeptide-8 (1000ppm)
Cosmetics
Code: 254324
Oil-soluble 1000ppm Acetyl Hexapeptide-8 concentrate for expression-line softening and anti-wrinkle concepts in oils, oil gels and emulsion systems.
PepOil™ Acetyl Hexapeptide-8 is an oil-compatible liquid concentrate of Acetyl Hexapeptide-8 for cosmetic formulas that need peptide benefits in an oil phase, oil gel, balm-serum or low-water emulsion system.
Acetyl Hexapeptide-8 (Argireline) is a synthetic cosmetic peptide patterned from SNAP-25 and used for expression-line and peri-orbital wrinkle concepts. Use the claim language as cosmetic appearance support, not as a medical or injectable-peptide claim.
This product is supplied as an oil-soluble 1000ppm active concentrate. The format helps formulators use the peptide in anhydrous oils, facial oils, balm-serums and oil phases where a conventional water-soluble peptide solution is not suitable.
Product Description: Use this product when the finished product needs expression-line softening and anti-wrinkle positioning but the formula architecture is oil based or low-water. Because this product contains 1000ppm Acetyl Hexapeptide-8, a 2–10% ingredient level delivers approximately 20–100ppm active peptide in the finished formula. A typical 5% use level delivers approximately 50ppm active peptide.
| Formulation target | Practical use | Technical note |
|---|---|---|
| Oil serum / facial oil | Blend during final oil-phase processing | Keep below 40°C after peptide addition |
| Oil gels and balm-serums | Pre-blend into liquid emollients before thickening | Check clarity, viscosity and package compatibility |
| W/O or emulsion products | Post-add into the oil phase or cool finished emulsion | Finished formula pH around 4–7.5 is preferred |
| Lip balm / lipstick | Pre-blend into the oil phase before wax structuring; add below 40°C when possible | Check clarity, payoff, glide and stability in the final stick or balm base |
Usage: anti-wrinkle serums, eye creams, facial oils, oil gels, balm-serums, W/O emulsions and expression-line care products.
Mixing method:
- Add during the final oil phase or cool-down stage. Keep product temperature below 40°C after addition.
- For oil gels or balm-serums, pre-blend into the liquid oil portion before adding delicate fragrance or heat-sensitive actives.
- Avoid strong oxidizing/reducing systems, high pH, prolonged heating and repeated freeze-thaw exposure. Run compatibility and stability checks in the final package.
Usage rate: 2–10% of this 1000ppm concentrate (delivers approximately 20–100ppm active Acetyl Hexapeptide-8). Typical: 5% → approximately 50ppm active.
Product characteristics: Clear to yellow liquid concentrate.
Solubility: Clearly dissolves in polar cosmetic oils and polar esters. For non-polar oils, pre-blend with a small amount of Oil Blender™ (Polyglyceryl-3 Diisostearate) until the concentrate becomes clear, then add to the oil phase. Not intended for direct addition to a purely aqueous phase.
Storage: keep tightly closed, protected from light and heat. Store cool when possible.
- Clear to yellow oil-soluble liquid concentrate
- Cool (15-25C)
- 24 Months from manufacturing or testing date.
- 2.00% - 10.00%
- 5.00%
- Dissolve in oil phase. Avoid temperature above 40C and light exposure.
- Heat Tolerant
- 4.00 - 7.50
- Soluble in Oil
- Cream, Serum, Oil-Based Serum, Facial Oil, Oil Gel, Anti-Aging Ingredient, Clear Oil Gel
“Acetyl Hexapeptide-8 scope: review summarizes skin permeability, in-vitro and in-vivo efficacy evidence for Argireline.”
“Acetyl Hexapeptide-8 formula scope: ex vivo and clinical serum study reports wrinkle and texture improvements in a peptide-containing formula.”
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