OliWhite™ (Oligopeptide-68 1000ppm Solution) is a TGF-beta biomimetic peptide brightening active supplied as a 1000 ppm Oligopeptide-68 solution in a cyclodextrin-based delivery system.

From a formulator perspective, this active is used as a melanogenesis-modulating system for leave-on tone-evening and spot-correction products rather than a fast keratolytic or oxidizing lightener. Its main value is upstream control of pigmentation signaling, especially MITF-linked pathways, with downstream reduction in tyrosinase activity and melanin synthesis.

The cyclodextrin format is intended to improve handling in water-based systems and support more gradual presentation of the peptide to skin. In practical use this favors low-heat, final-step addition and repeated leave-on application for progressive brightening, more uniform-looking tone, and reduced visible spot intensity over time.

Product Description: Research on encapsulated Oligopeptide-68 systems supports activity at both mechanistic and visible-performance levels. In melanocyte models, Oligopeptide-68 has been associated with lower MITF signaling, lower TRP-1 / TRP-2 expression, reduced tyrosinase-driven melanogenesis, and reduced melanin accumulation including under alpha-MSH stimulation. In human use, an encapsulated Oligopeptide-68 brightening system applied twice daily in Asian skin showed progressive brightness improvement and lower visible spot darkness by day 28 and day 56. A separate longer-duration combination depigmenting regimen that included the same peptide family also reported acceptable tolerance and improvement versus baseline. The evidence is strongest for progressive tone-evening support in leave-on use;

Usage: Brightening serums, spot-correction gels, tone-evening essences, gel-creams, lotions, masks, and post-sun or anti-photoaging products designed to improve the appearance of uneven skin tone and pigmented spots.

Mixing method:

- Add during cool-down at the final stage, preferably below 40°C, into the water phase or after emulsion formation.

- Best development range is mildly acidic to near-neutral. Target about pH 5.0-6.5 in routine work; practical use around pH 4.0-8.0 should still be confirmed in the final system.

- Compatible with aqueous serums, gels, O/W emulsions, glycerin and common glycols. Validate carefully in very low-pH acid systems, strong oxidizing systems, highly ionic systems, or prolonged hot processing.

- Works best in leave-on products with repeated daily use. If paired with niacinamide, N-acetyl glucosamine, tranexamic-acid derivatives, licorice flavonoids, or gentle exfoliation systems, re-check stability and sensory in the final formula.

Usage rate: 0.5-5%

This 1000 ppm solution delivers approximately 0.0005-0.005% Oligopeptide-68 active in the final formula (about 5-50 ppm active). A practical screening range is 1-3%; more assertive leave-on brightening concepts may use 3-5% after stability and claim validation.

Product characteristics: Clear to slightly opalescent, colorless to pale yellow liquid.

Solubility: Water and glycol compatible delivery system; easiest to formulate in serums, essences, gels, and O/W emulsions. Not intended as a direct oil-phase ingredient.

Storage: Store tightly closed, protected from light and heat. Controlled cool storage is preferred. Avoid repeated freeze-thaw exposure and long hold times in hot bulk.