Dimethyl 2-([1,1'-biphenyl]-4-yl)malonate is widely used in organic synthesis as a key intermediate for the preparation of various pharmaceutical compounds. Its structure allows for versatile chemical transformations, making it valuable in the development of drugs targeting inflammation, cancer, and cardiovascular diseases. The compound is often employed in the synthesis of biphenyl derivatives, which are crucial in medicinal chemistry due to their biological activity. Additionally, it serves as a building block in the production of fine chemicals and agrochemicals, where its malonate group can be easily modified to create complex molecules. Its role in cross-coupling reactions further enhances its utility in constructing diverse organic frameworks.