XMD8-92 is primarily utilized in biomedical research as a selective inhibitor of the ERK5 (extracellular signal-regulated kinase 5) signaling pathway. Its application is significant in studying the role of ERK5 in various cellular processes, including cell proliferation, differentiation, and survival. Researchers employ XMD8-92 to investigate its potential therapeutic effects in diseases where ERK5 signaling is implicated, such as cancer, cardiovascular diseases, and inflammatory conditions. By inhibiting ERK5, XMD8-92 helps in understanding the molecular mechanisms underlying these diseases and aids in the development of targeted therapies. Additionally, it is used in preclinical studies to assess the efficacy and safety of ERK5 inhibition as a treatment strategy.