UIO-66-Br is widely used in catalysis due to its enhanced Lewis acidity from the bromine functional group, making it effective in organic transformations such as oxidation and coupling reactions. Its high surface area and stability allow for efficient reactant adsorption and catalyst recyclability. It is also employed in gas separation processes, particularly for CO₂ capture, where the bromine moiety improves selectivity toward acidic gases. Additionally, UIO-66-Br shows promise in photodegradation of pollutants under visible light, acting as a semiconductor-like photocatalyst. The material’s tunable porosity and functional sites make it suitable for targeted drug delivery and sensing applications, especially for detecting electron-deficient analytes.