ACPT-II is primarily utilized in neuroscience research due to its role as a selective agonist for group III metabotropic glutamate receptors (mGluRs). It is extensively used in studies aimed at understanding the function and modulation of these receptors in the central nervous system. Researchers employ ACPT-II to investigate its effects on synaptic transmission, neuronal excitability, and neuroprotection. Its application is particularly valuable in exploring potential therapeutic strategies for neurological disorders such as epilepsy, anxiety, and neurodegenerative diseases like Parkinson's and Alzheimer's. Additionally, ACPT-II helps in elucidating the mechanisms underlying synaptic plasticity and long-term potentiation, which are critical for learning and memory processes.