ADX47273 is primarily used in research settings to study its effects on the metabotropic glutamate receptor 5 (mGluR5). It acts as a positive allosteric modulator, enhancing the receptor's response to glutamate. This makes it a valuable tool in neuroscience for investigating the role of mGluR5 in various neurological and psychiatric conditions, such as anxiety, depression, schizophrenia, and Parkinson's disease. Researchers utilize ADX47273 to explore potential therapeutic applications, including the development of treatments for cognitive disorders and neurodegenerative diseases. Its ability to modulate glutamate signaling also aids in understanding synaptic plasticity and brain function.