JNJ16259685 is primarily utilized in research settings to study the role of mGlu1 receptors in the central nervous system. It serves as a potent and selective antagonist for these receptors, helping scientists understand their function in various neurological processes. This compound has been instrumental in investigating conditions such as anxiety, pain, and neurodegenerative diseases. By blocking mGlu1 receptors, it provides insights into their involvement in synaptic transmission and plasticity. Additionally, JNJ16259685 is used in preclinical studies to explore potential therapeutic targets for disorders like Parkinson’s disease and epilepsy, offering valuable data for developing new treatments.