VU0357017 hydrochloride is a selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5), primarily used in research settings to study the enhancement of mGlu5 receptor activity in cellular signaling pathways. It is valuable for investigating the physiological and pathological functions of mGlu5 receptors in the central nervous system and other tissues. Researchers utilize this compound to explore its potential therapeutic applications in conditions such as schizophrenia, anxiety disorders, fragile X syndrome, and other neurological disorders related to glutamatergic dysfunction. Its ability to potentiate receptor activity provides insights into the development of targeted treatments for these conditions. Additionally, it is employed in preclinical studies to understand its pharmacokinetics and pharmacodynamics, aiding in the design of future drugs.