VU6005649 is primarily used in neuroscience research to study and modulate specific neurological pathways. It acts as a selective negative allosteric modulator for certain receptors in the brain, making it valuable for investigating conditions like anxiety, depression, and other mood disorders. Researchers utilize it to understand receptor behavior and develop potential therapeutic interventions. Its application is limited to preclinical studies, where it helps elucidate the role of targeted receptors in brain function and disease mechanisms.