Tonabersat is primarily investigated for its potential therapeutic applications in neurological and vascular conditions. It is a gap junction modulator, which means it can influence the communication between cells, particularly in the brain. One of its key areas of research is in the treatment of migraines, where it is believed to reduce the frequency and severity of attacks by modulating cortical spreading depression, a phenomenon linked to migraine aura. Additionally, Tonabersat has been explored for its potential in managing epilepsy, as it may help stabilize neuronal activity and prevent seizures. There is also emerging interest in its application for neuroprotection, particularly in conditions like stroke, where it could help minimize brain damage by improving cellular resilience. Its role in reducing inflammation and protecting the blood-brain barrier further highlights its potential in treating various central nervous system disorders.