AminoHA™ (Sodium N-Hyaluronoyl Glutamate)

AminoHA™ (Sodium N-Hyaluronoyl Glutamate)
Cosmetics Code: 253975

Water-soluble sodium hyaluronoyl glutamate powder linking low-MW HA with glutamate for barrier hydration, AQP3 support, TEWL reduction, and calming support in leave-on skincare.

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AminoHA (Sodium N-Hyaluronoyl Glutamate) is a water-soluble bioactive powder made by covalently linking low-molecular-weight hyaluronic acid with glutamic acid through an amide bond.

The technology combines a selected HA fraction in the approximate 30k-50k Da range with the skin-relevant glutamate structure. The HA segment is positioned for CD44-related barrier and repair signaling, while the glutamate segment supports the skin's natural moisturizing factor (NMF) environment and indirectly supports ceramide/lipid-barrier biology.

Use AminoHA in leave-on formulas for hydration, barrier recovery, sensitive-skin support, acne-prone skin support, and fragile barrier care where a low-dose, water-phase active is preferred.

Product Description: AminoHA is based on acyl-glutamate technology: the carboxyl group of low-molecular-weight hyaluronic acid is bonded to the amino group of glutamic acid, forming a dual-effect molecule that supports moisture binding, skin-barrier recovery, and calm-skin positioning. Low-molecular-weight HA in the supplied technical data is selected around 30k-50k Da for interaction with CD44 receptor biology, which is associated with keratinocyte/fibroblast activity, cell proliferation and migration, immune regulation, and moderation of inflammatory response. The glutamate side contributes to the NMF pool, helps maintain a weakly acidic skin surface environment, and is positioned to support ceramide synthesis and lipid-barrier quality.

The supplied efficacy package includes a 3D SLS injury model, keratinocyte AQP3 expression, in-vivo TEWL response, and UV-stressed fibroblast inflammatory-marker data. The evidence should be interpreted as ingredient-level support data for cosmetic barrier, hydration, and soothing claims, not as a drug or wound-treatment claim.

Model/System Use Level / Groups Endpoint / Result Formulation Meaning
3D skin-SLS injury model Control; SLS model; PC: Pirinixic acid; 500 ppm AminoHA; 50 um scale bar Source panel states AminoHA accelerated reconstruction and repair of damaged skin, strengthened newly formed skin, and revitalized damaged skin. Barrier-recovery support for stressed or compromised skin formulas.
Human keratinocyte HaCaT model vs deionized-water placebo 0.01%, 0.05%, 0.10% AminoHA AQP3 relative expression increased +7.08% (*), +9.66% (**), and +10.27% (***) respectively. Supports hydration-channel and barrier-function positioning.
SLS damage model, in-vivo forearm flexor, 30 volunteers aged 23-60 years 0.1% and 0.5% AminoHA vs deionized-water placebo TEWL change rate: day 1, 0.1% = -13.52% (*); day 1, 0.5% bar shown without numeric source label; day 7, 0.1% = -5.62% (**); day 7, 0.5% = -3.82% (*). Useful in barrier-repair serums, gels, creams, lotions, masks, and sensitive-skin products.
Fibroblast HDFs-UV model AminoHA 150 ppm vs UV model and physical mixture 150 ppm IL-6 gene relative expression: AminoHA -86.8% (*** vs UV; significant vs physical mixture), physical mixture -38.5% (* vs UV). IL-1alpha: AminoHA -23.4% (** vs UV), physical mixture -17.5% (** vs UV). Source legend notes ##p<0.01 vs physical mixture for the comparison. Supports soothing and immune-homeostasis language for UV- or irritation-stressed skin.

The COA profile supports a white powder with characteristic odor, readily soluble in water and almost insoluble in ethanol. Key QC values include pH 4.0-7.0 in 0.2% aqueous solution (batch result 6.2), transparency >=99.0% (result 99.8%), degree of substitution 40.0-60.0% (result 55.56%), molecular weight 10-200 kDa (result 47 kDa), assay 85.0-105.0% on dried substance (result 99.98%), loss on drying <=15.0% (result 8.70%), metals as lead <=10 ppm, arsenic <=2 ppm, bacteria <=100 CFU/g, mold & yeast <=50 CFU/g, and negative results for Staphylococcus aureus, Pseudomonas aeruginosa, and thermotolerant coliform bacteria.

Usage: Suitable for leave-on facial serums, water gels, creams, lotions, toners, masks, sensitive-skin products, acne-prone skin support formulas, post-stress barrier products, and fragile-barrier skincare.

Mixing method:

- Dissolve in the water phase or pre-dissolve in purified water before addition. Add during cool-down or at room temperature; avoid prolonged high heat.

- Keep the final formula in a skin-compatible pH range, preferably around pH 4.0-7.0. Avoid strongly acidic or strongly alkaline systems.

- Stir gently until fully dissolved. Avoid excessive high-shear mixing after hydration to preserve polymer-like sensory and performance behavior.

- Compatible with typical aqueous humectant systems such as glycerin, propanediol, butylene glycol, betaine, panthenol, sodium PCA, and conventional emulsion/gel bases.

Usage rate: 0.01-0.5%

For targeted barrier and soothing positioning, 0.1% is a practical starting level; 0.5% is suitable when a stronger active-positioning story is desired and the formula can tolerate the added polymer/humectant load.

Product characteristics: White to off-white powder; characteristic odor; molecular weight range 10-200 kDa with supplied batch result 47 kDa; assay 85.0-105.0% on dried substance.

Solubility: Readily soluble in water; almost insoluble in ethanol. Not oil-soluble.

Storage: Store tightly closed in a cool, dry place away from moisture and direct light. Reseal immediately after use to limit moisture uptake.


  • -
Test Name Specification
Character White or white like powder or
Odor Characteristic odor
Solubility Readily soluble in water, almost insoluble in ethanol
infrared spectrum The infrared spectrum of the test sample exhibits absorption peaks near the following wavenumbers (cm-1).3418cm⁻¹(b), 1651cm⁻¹(s), 1558cm⁻¹(m), 1317cm⁻¹, 1150cm⁻¹
Transparency, % ≥99.0
pH value (0.2% aqueous solution) 4.0~7.0
*Degree of substitution, % 40.0~60.0
Molecular weight, KDa 10~200
Assay (dried substance), % 85.0~105.0
Loss on drying, % ≤15.0
Metal (calculated as lead), ppm (equivalent to mg/kg) ≤10
Arsenic, ppm ≤2
Bacteria counts, CFU/g ≤100
Mold & Yeast, CFU/g ≤50
Staphylococcus aureus/g Negative
Pseudomonas aeruginosa/g Negative
Thermotolerant coliform bacteria /g Negative

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AminoHA™ (Sodium N-Hyaluronoyl Glutamate)

Water-soluble sodium hyaluronoyl glutamate powder linking low-MW HA with glutamate for barrier hydration, AQP3 support, TEWL reduction, and calming support in leave-on skincare.

AminoHA (Sodium N-Hyaluronoyl Glutamate) is a water-soluble bioactive powder made by covalently linking low-molecular-weight hyaluronic acid with glutamic acid through an amide bond.

The technology combines a selected HA fraction in the approximate 30k-50k Da range with the skin-relevant glutamate structure. The HA segment is positioned for CD44-related barrier and repair signaling, while the glutamate segment supports the skin's natural moisturizing factor (NMF) environment and indirectly supports ceramide/lipid-barrier biology.

Use AminoHA in leave-on formulas for hydration, barrier recovery, sensitive-skin support, acne-prone skin support, and fragile barrier care where a low-dose, water-phase active is preferred.

Product Description: AminoHA is based on acyl-glutamate technology: the carboxyl group of low-molecular-weight hyaluronic acid is bonded to the amino group of glutamic acid, forming a dual-effect molecule that supports moisture binding, skin-barrier recovery, and calm-skin positioning. Low-molecular-weight HA in the supplied technical data is selected around 30k-50k Da for interaction with CD44 receptor biology, which is associated with keratinocyte/fibroblast activity, cell proliferation and migration, immune regulation, and moderation of inflammatory response. The glutamate side contributes to the NMF pool, helps maintain a weakly acidic skin surface environment, and is positioned to support ceramide synthesis and lipid-barrier quality.

The supplied efficacy package includes a 3D SLS injury model, keratinocyte AQP3 expression, in-vivo TEWL response, and UV-stressed fibroblast inflammatory-marker data. The evidence should be interpreted as ingredient-level support data for cosmetic barrier, hydration, and soothing claims, not as a drug or wound-treatment claim.

Model/System Use Level / Groups Endpoint / Result Formulation Meaning
3D skin-SLS injury model Control; SLS model; PC: Pirinixic acid; 500 ppm AminoHA; 50 um scale bar Source panel states AminoHA accelerated reconstruction and repair of damaged skin, strengthened newly formed skin, and revitalized damaged skin. Barrier-recovery support for stressed or compromised skin formulas.
Human keratinocyte HaCaT model vs deionized-water placebo 0.01%, 0.05%, 0.10% AminoHA AQP3 relative expression increased +7.08% (*), +9.66% (**), and +10.27% (***) respectively. Supports hydration-channel and barrier-function positioning.
SLS damage model, in-vivo forearm flexor, 30 volunteers aged 23-60 years 0.1% and 0.5% AminoHA vs deionized-water placebo TEWL change rate: day 1, 0.1% = -13.52% (*); day 1, 0.5% bar shown without numeric source label; day 7, 0.1% = -5.62% (**); day 7, 0.5% = -3.82% (*). Useful in barrier-repair serums, gels, creams, lotions, masks, and sensitive-skin products.
Fibroblast HDFs-UV model AminoHA 150 ppm vs UV model and physical mixture 150 ppm IL-6 gene relative expression: AminoHA -86.8% (*** vs UV; significant vs physical mixture), physical mixture -38.5% (* vs UV). IL-1alpha: AminoHA -23.4% (** vs UV), physical mixture -17.5% (** vs UV). Source legend notes ##p<0.01 vs physical mixture for the comparison. Supports soothing and immune-homeostasis language for UV- or irritation-stressed skin.

The COA profile supports a white powder with characteristic odor, readily soluble in water and almost insoluble in ethanol. Key QC values include pH 4.0-7.0 in 0.2% aqueous solution (batch result 6.2), transparency >=99.0% (result 99.8%), degree of substitution 40.0-60.0% (result 55.56%), molecular weight 10-200 kDa (result 47 kDa), assay 85.0-105.0% on dried substance (result 99.98%), loss on drying <=15.0% (result 8.70%), metals as lead <=10 ppm, arsenic <=2 ppm, bacteria <=100 CFU/g, mold & yeast <=50 CFU/g, and negative results for Staphylococcus aureus, Pseudomonas aeruginosa, and thermotolerant coliform bacteria.

Usage: Suitable for leave-on facial serums, water gels, creams, lotions, toners, masks, sensitive-skin products, acne-prone skin support formulas, post-stress barrier products, and fragile-barrier skincare.

Mixing method:

- Dissolve in the water phase or pre-dissolve in purified water before addition. Add during cool-down or at room temperature; avoid prolonged high heat.

- Keep the final formula in a skin-compatible pH range, preferably around pH 4.0-7.0. Avoid strongly acidic or strongly alkaline systems.

- Stir gently until fully dissolved. Avoid excessive high-shear mixing after hydration to preserve polymer-like sensory and performance behavior.

- Compatible with typical aqueous humectant systems such as glycerin, propanediol, butylene glycol, betaine, panthenol, sodium PCA, and conventional emulsion/gel bases.

Usage rate: 0.01-0.5%

For targeted barrier and soothing positioning, 0.1% is a practical starting level; 0.5% is suitable when a stronger active-positioning story is desired and the formula can tolerate the added polymer/humectant load.

Product characteristics: White to off-white powder; characteristic odor; molecular weight range 10-200 kDa with supplied batch result 47 kDa; assay 85.0-105.0% on dried substance.

Solubility: Readily soluble in water; almost insoluble in ethanol. Not oil-soluble.

Storage: Store tightly closed in a cool, dry place away from moisture and direct light. Reseal immediately after use to limit moisture uptake.

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