VU 0238429 is primarily used in research settings to study the role of specific receptors in the brain, particularly those involved in neurological and psychiatric disorders. It acts as a selective positive allosteric modulator, enhancing the activity of certain receptors without directly activating them. This property makes it valuable for investigating conditions like schizophrenia, Parkinson's disease, and cognitive impairments. Researchers utilize it to explore potential therapeutic pathways and better understand the underlying mechanisms of these disorders. Its application is largely confined to preclinical studies, where it helps in developing new insights into receptor function and drug discovery.