Fumonisin B3 (FB3) is primarily studied in the context of its role as a mycotoxin, a toxic compound produced by certain molds, particularly Fusarium species. Its applications and significance are largely related to its impact on agriculture, food safety, and health. In agriculture, FB3 is a concern due to its presence in crops such as corn, where it can contaminate grains and pose risks to livestock and humans. Its detection and monitoring are critical for ensuring the safety of food and feed products. Researchers focus on developing methods to mitigate its presence, such as improving crop storage conditions and breeding resistant plant varieties. In health and toxicology, FB3 is studied for its potential adverse effects on humans and animals. It is known to disrupt sphingolipid metabolism, which can lead to cellular damage and contribute to diseases such as cancer and neural tube defects. Understanding its mechanisms of toxicity helps in assessing risks and establishing regulatory limits for exposure. Additionally, FB3 serves as a biomarker in research to study the effects of mycotoxin exposure and to evaluate the efficacy of detoxification strategies. Its role in scientific studies contributes to advancing knowledge in food safety and public health.