DS-437 is primarily utilized in research settings as a potent and selective inhibitor of the enzyme nicotinamide phosphoribosyltransferase (NAMPT). This enzyme plays a crucial role in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a vital coenzyme involved in various cellular processes, including energy metabolism and DNA repair. By inhibiting NAMPT, DS-437 is used to study the effects of NAD+ depletion in cells, which can lead to insights into cancer biology, as many cancer cells rely heavily on NAD+ for their rapid proliferation. Additionally, DS-437 serves as a valuable tool in pharmacological studies aimed at developing new therapeutic strategies for cancer treatment by targeting NAD+ metabolism. Its application extends to exploring the potential of NAMPT inhibition in other diseases where NAD+ dysregulation is implicated, such as neurodegenerative disorders and metabolic syndromes.