Berbamine is widely studied for its potential anticancer properties, particularly in targeting drug-resistant cancer cells such as leukemia, breast, and liver cancers. It has shown ability to inhibit the growth of various tumor types by inducing apoptosis and blocking cell cycle progression. Research also highlights its role in suppressing multidrug resistance in cancers by modulating P-glycoprotein and other drug efflux pumps.

In addition to oncology, berbamine exhibits anti-inflammatory and immunomodulatory effects, making it a candidate for managing autoimmune diseases and chronic inflammation. It has been explored for cardiovascular protection due to its calcium channel blocking activity, which may help in treating arrhythmias and hypertension.

Emerging studies suggest berbamine can support liver health by reducing oxidative stress and inflammation in liver tissues, indicating potential use in treating liver diseases such as hepatitis and fatty liver disease. It also demonstrates neuroprotective effects, potentially beneficial for neurodegenerative conditions like Alzheimer's disease. Additionally, it shows antimicrobial activity against certain pathogens, including fungi and bacteria, broadening its therapeutic scope.

Due to its diverse biological activities, berbamine is considered a promising lead compound for developing new drugs, especially in integrative and complementary medicine approaches. However, its use remains primarily in the research stage and is not yet widely applied in clinical settings.