Sacubitrilat

≥99%

Reagent Code: #102447
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CAS Number 149709-44-4

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 383.44 g/mol
Formula C₂₂H₂₅NO₅
inventory_2 Storage & Handling
Storage 2-8℃

description Product Description

Sacubitrilat is the active metabolite of sacubitril and serves as a neprilysin inhibitor in the treatment of chronic heart failure. It is a key component in the fixed-dose combination drug sacubitril/valsartan, marketed under the brand name Entresto, where sacubitril is rapidly converted to sacubitrilat in the body. By inhibiting neprilysin, sacubitrilat increases levels of natriuretic peptides, promoting vasodilation, natriuresis, and diuresis, which reduce blood pressure and fluid overload. This mechanism improves cardiac function, manages symptoms, and lowers the risk of hospitalization in patients with heart failure with reduced ejection fraction.

format_list_bulleted Product Specification

Test Parameter Specification
Appearance White Solid
Purity (%) 98.5-100%
Infrared Spectrum Conforms To Structure

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory bulk
10-20 days ฿0.00
inventory 5mg
10-20 days ฿3,080.00
inventory 10mg
10-20 days ฿4,980.00
inventory 2mg
10-20 days ฿2,290.00

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