Sacubitrilat
≥99%
Reagent
Code: #102447
CAS Number
149709-44-4
blur_circular Chemical Specifications
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Molecular Information
Weight
383.44 g/mol
Formula
C₂₂H₂₅NO₅
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Storage & Handling
Storage
2-8℃
description Product Description
Sacubitrilat is the active metabolite of sacubitril and serves as a neprilysin inhibitor in the treatment of chronic heart failure. It is a key component in the fixed-dose combination drug sacubitril/valsartan, marketed under the brand name Entresto, where sacubitril is rapidly converted to sacubitrilat in the body. By inhibiting neprilysin, sacubitrilat increases levels of natriuretic peptides, promoting vasodilation, natriuresis, and diuresis, which reduce blood pressure and fluid overload. This mechanism improves cardiac function, manages symptoms, and lowers the risk of hospitalization in patients with heart failure with reduced ejection fraction.
format_list_bulleted Product Specification
| Test Parameter | Specification |
|---|---|
| Appearance | White Solid |
| Purity (%) | 98.5-100% |
| Infrared Spectrum | Conforms To Structure |
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