AHU-377 sodium salt is primarily used in pharmaceutical research and development, particularly as an active ingredient in the treatment of heart failure. It functions as a neprilysin inhibitor, helping to increase the levels of beneficial peptides in the cardiovascular system, such as natriuretic peptides, which promote vasodilation, diuresis, and reduced blood pressure. By inhibiting neprilysin, it supports the reduction of cardiac workload and helps slow disease progression in patients with heart failure. It is often combined with other agents, such as angiotensin receptor blockers, to enhance therapeutic efficacy. Its sodium salt form improves solubility and bioavailability, making it suitable for oral dosage forms in clinical settings.