Used primarily in the treatment of chronic heart failure, it works by inhibiting the enzyme neprilysin, which helps in reducing the breakdown of beneficial peptides that promote vasodilation and sodium excretion. This action aids in improving heart function and reducing symptoms such as shortness of breath and fatigue. It is often combined with valsartan to enhance its efficacy, providing a dual mechanism of action that addresses both the hormonal and structural aspects of heart failure. This combination has shown significant benefits in reducing hospitalizations and improving the quality of life for patients with reduced ejection fraction heart failure.