KV2 channel inhibitor-1 is primarily used in neuroscience research to modulate voltage-gated potassium channels, specifically the KV2 subtype. It helps in studying the role of these channels in neuronal excitability and action potential regulation. The compound is valuable for investigating cellular mechanisms underlying neurodegenerative diseases, stroke, and epilepsy, where abnormal potassium currents contribute to pathology. It is also employed in electrophysiology experiments to dissect KV2 channel function in isolation from other potassium channel types. Due to its selectivity, it serves as a tool compound in developing more targeted neuroprotective therapies.