Used in neuroscience research to quantify total tau protein levels in cerebrospinal fluid (CSF) and brain tissue samples. Helps in studying neurodegenerative diseases, particularly Alzheimer's disease, where elevated levels of total tau are a biomarker for neuronal damage. Enables researchers to assess disease progression, evaluate therapeutic interventions, and support diagnosis in clinical research settings. Widely applied in biomarker validation, drug development studies, and cognitive disorder investigations.