Calcitonin gene-related peptide fragment 8-37 (CGRP 8-37) is widely used in research to study the physiological and pathological roles of CGRP. It acts as a selective antagonist of CGRP receptors, making it a valuable tool for investigating the involvement of CGRP in various biological processes. This fragment is particularly useful in studies related to pain mechanisms, as CGRP is known to play a significant role in migraine and other pain disorders. Researchers use CGRP 8-37 to block CGRP signaling, helping to elucidate its contribution to vasodilation, neurogenic inflammation, and nociception. Additionally, it is employed in cardiovascular research to explore CGRP's effects on blood pressure and heart function. Its application extends to neurological studies, where it helps understand CGRP's role in neurotransmission and its potential as a therapeutic target for neurological conditions.