WAY-225588 is primarily used in neuroscience research as a potent and selective agonist for the ghrelin receptor (Growth Hormone Secretagogue Receptor, GHS-R1a). It is utilized to study the physiological effects of ghrelin signaling, including appetite regulation, energy balance, and growth hormone release. Due to its ability to cross the blood-brain barrier, it is valuable in investigating central nervous system pathways related to feeding behavior and metabolic disorders. It has also been explored in preclinical studies for its potential neuroprotective effects and role in cognitive function, particularly in models of neurodegenerative diseases. Its selectivity makes it a useful pharmacological tool for distinguishing ghrelin-mediated effects from other hormonal pathways.