Mesembrine is primarily known for its presence in the plant Sceletium tortuosum, traditionally used by indigenous South African cultures for its mood-enhancing and stress-relieving properties. In modern applications, it is studied for its potential as a natural antidepressant and anxiolytic agent due to its ability to inhibit the reuptake of serotonin, which can help improve mood and reduce anxiety. It is also explored for its cognitive-enhancing effects, potentially aiding in focus and mental clarity. Additionally, mesembrine is incorporated into dietary supplements and herbal remedies aimed at promoting emotional well-being and relaxation. Its use in skincare products is also emerging, as it may help reduce stress-related skin conditions.